Azithromycin is Azithromycin is a macrolide antibiotic active in vitro to treat major pathogens that cause infections of the respiratory tract, other tissues and According to Wilson, Hannon and Shields, these are: “bacterial infections, acute bacterial sinusitis, otitis media, pneumonia, tonsillitis or pharyngitis. » (2014) It is manufactured under the trade name Azasite, Zithromax and Zmax. Azithromycin works by entering the 50S ribosomal subunit of susceptible microorganisms and blocking their regular protein-making process. Azithromycin is contraindicated in patients with an allergic reaction to its components. In addition to this, it is also dangerous for patients with a history of jaundice and liver disease caused by the use of this drug in the past. On the other hand, to be safe before taking the medication, patients should inform their treating physician if they suffer from the following conditions: liver disease, kidney disease, myasthenia gravis or heart rhythm disorder. Azithromycin should not be used with digoxin, cyclosporine, phenytoin, dihydroergotamine and ergotamine, as it may increase the level of toxicity of these drugs. Foods can also reduce their absorption capacity to half of their full potential. Azithromycin should be used with caution in elderly people with hepatic or renal insufficiency, gastrointestinal diseases, breastfeeding and children younger than 6 months. On the other hand, according to one study, the ability of the macrolide class of antibiotics to contraindicate with certain other drugs is widely known. According to Westphal's 2000 study: "Macrolides can induce their own hepatic biotransformation into nitrosoalkanes, which later form inactive CYP3A4-iron metabolite complexes to prevent the formation of C...... middle of paper.. ....should first reconstitute to the final concentration of 100 mg/ml, then the solution should be further diluted to 1 mg/ml or 2 mg/ml by adding 5 ml of the original solution to 500 ml or 250 ml of normal saline or other compatible solution. It should be administered over 3 hours for 1 mg/ml or over 1 hour for 2 mg/ml for intermittent administration, and for the oral form, one hour before or two hours after a meal. Besides this, a key element to educate the patient and their family is to minimize direct sunlight during treatment. They can only take magnesium or aluminum 2 hours before or after taking this medicine. On the other hand, when administering azithromycin to the patient, the nurse should monitor for the presence of loose stools or diarrhea, closely monitor PT and INR in case of concomitant use of warfarin, and especially report any signs and symptoms of hypersensitivity, as this can be serious even if it is a patient. is rare.