Screening pregnant women for depression is part of routine antenatal care provided by midwives at Nambour General Hospital. Depression screening takes place at appointment and again at 36 weeks gestation using the Edinburgh Postnatal Depression Scale (EPDS). The aim of this trial is to evaluate the usefulness of prenatal screening for depression using the EPDS. Current evidence will be considered and the role of midwives, in using a positive midwife-wife relationship when administering the EPDS, will be discussed. Evidence-based recommendations will be made regarding the future direction of screening for antenatal depression in midwifery practice. The strategy used to locate resources when researching the usefulness of EPDS in pregnancy included a search on Google Scholar, all databases available through the FIND OUT! search function and search for articles referenced by the authors of informative articles already searched. Database searches were limited to scientific journals published between 2009 and 2014. Search terms included a combination of the following words and terms: Edinburgh Postnatal Depression Scale, EPDS, antenatal depression, depression, pregnancy, depression screening and midwife* (truncated to search for midwives). , midwife and midwife). This research strategy has resulted in ten recently published articles on the subject. Depression is not uncommon among pregnant women. Around one in five women suffer from depression during pregnancy (Marcus et al., 2003 cited in Jones et al., 2012). Factors leading to depression during pregnancy include biological and psychological processes (Breedlove & Fryzelka, 2011), biochemical changes in the brain due to fluctuations in hormone levels...... middle of article.. .... rth, 25(1), p. 23-28. doi:10.1016/j.wombi.2011.03.001Matthey, S. and Ross-Hamid, C. (2012). Repeat testing of the Edinburgh Depression Scale and HADS-A during pregnancy: differentiating between transient and lasting distress. Journal of Affective Disorders, 141(2), pages 213-221. doi: 10.1016/j.jad.2012.02.037Rollans, M., Schmied, V., Kemp, L., and Meade, T. (2013). Digging this old ground: an Australian perspective on women's experiences of psychosocial assessment and depression screening during pregnancy and postpartum. BMC Women's Health, 13(1), p. 18-32. doi: 10.1186/1472-6874-13-18Thombs, B., Arthurs, E., Coronado-Montoya, S., Roseman, M., Delisle, V. and Leavens, A. et al. (2014). Depression screening and patient outcomes during pregnancy or postpartum: a systematic review. Journal of Psychosomatic Research, pp. 1-14. doi: 10.1016/j.jpsychore.2014.01.006