Immunotoxicity: It is defined as a condition in which an immunotoxin negatively affects the immune system. An immunotoxin is a human-made protein that consists of a protein linked to a toxin. The protein works by “targeting” specific cells, which are killed when the protein binds to those cells and the toxin is absorbed through a process called “endocytosis.” Immunotoxicity includes direct toxicity to components of the immune system, resulting in suppression of function or unintended stimulation. The immune system consists of a complex network of cells and soluble mediators that interact in a highly regulated manner to generate immune responses. Therefore, inappropriate immune responses can lead to allergic and autoimmune diseases.NSAIDs:NSAIDs (non-steroidal anti-inflammatory drugs) have antipyretic and anti-inflammatory actions in different extents. They act primarily on peripheral pain mechanisms and do not cause physical dependence or depress the CNS. Although the risk of adverse effects from NSAIDs increases with long-term use, they are a reliable and effective treatment for controlling moderate pain. The most common NSAIDs are aspirin, phenylbutazone, diclofenac, paracetamol, ibuprofen and ketoprofen. Few NSAIDs and their structures: AspirinUses: In addition, having regular antipyretic and anti-inflammatory effects, it is believed to have antioxidant effects (Ataollah, 2011). ) via its ability to eliminate OH radicals.Ibuprofen:Uses: Treatment of migraine (Evers, 2011)Paracetamol:Uses: Most common household medicineMechanism:There are different types of cyclooxygenase (COX) enzymes in... . middle of paper ......Early pregnancy linked to risk of miscarriage, Canadian Medical Association Journal, 110454.4. Mennear, John H, White, Kimber L; Komocsar, Wendy J.; Khan, K. Nasir;. Jr.; Furst, Sylvia M.; Peachee, Vanessa L.; Screening drugs for their immunotoxic potential: I. Evaluation of the effects of conventional nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors on phagocytic activity in vitro and in vivo, 2004, Vol-1,149-158.5. Kushima, Kiyoshi; Fujiwara, Michio; Oda, Keiko; Sakuma, Shozo; Furusawa, Shuichi; Effect of prenatal NSAID administration on immune response in juveniles and adults, 2007, Vol-232,257-267.6. PanahYab, Ataollah; Bagheri Sadeghi, Golshan; Nafisi, Shohreh; Interaction of aspirin and vitamin C with bovine serum albumin, 2011,105,198-202.7. Husstedt, IW; Evers, S. Migraine in Pregnancy and Breastfeeding, 2011, 44, 969-973