Interest in the study of Rhesus disease stems from the aspiration to understand blood and its components at the cellular level. In order to recognize which factors lead to this disease and which components of the cell can be used as indicators/markers to diagnose it, one must have a general idea of ​​the concepts involved in cellular processes. This article will focus on the causes of hemolytic disease, including natural and/or surgical and medicinal events that cause isoimmunization; how antigens and antibodies are involved as well as the effectiveness of Rh immunoglobulin will also be considered. The nature of Rh disease or Rh isoimmunization comes from the Rh factor, which is a protein that can be found on the surface of red blood cells. Carrying this protein means a person is Rh⁺ while someone who does not carry the protein is Rh⁻. Rh status is determined by the mother and father; if one parent is Rh⁺ and the other is Rh⁻, the baby has at least a 50% chance of being Rh⁺. Due to the fact that people are genetically predetermined to have or not have the Rh factor, there is sometimes an event where an Rh⁻ woman is pregnant with an Rh⁺ child. Problems can then arise if the baby's blood enters the mother's blood; the baby's Rh⁺ blood causes the mother's body to create antibodies against it. These antibodies will then attack all Rh⁺ blood cells. This does not cause any harm to the mother but can create complications for the baby if the antibodies reach the baby and destroy some of the baby's blood cells. This is called isoimmunization; this only occurs if the baby's Rh⁺ blood enters the bloodstream, unless a woman becomes sensitized to Rh blood when she has received an incompatible disease...... middle of paper ... ...y conqueror. Works Cited Arthur, GR, Foote, G., Page, C., Scott, JS, Thornton, JG, Tovey, LA 1989. Efficacy and long-term effects of antenatal prophylaxis with anti-D immunoglobulin. British Medical Journal. V.298 (6689). P. 1671-1673. Clinical and experimental immunology. 1983. IUSI/WHO Opinion: Appropriate uses of human immunoglobulin in clinical practice. The Journal of Translational Immunology. V. 52 (2). P. 417-422.Holder, WT, McCord, DL and Turner, Ralph J. 1984. Isoimmunization with anti-U antibody. Journal of the National Medical Association. V.76 (3). P. 277-283.Perinatol, J. 2011. Fetal intraperitoneal immunoglobulin injection reduces alloimmune hemolysis. Journal of Perinatology. V. 31. P. 289-292.Whitehouse, WL 1968. Rh isoimmunization and therapeutic abortion. British Medical Journal. V.2 (5659). Page. 759-760.