Regional drug delivery by transdermal administration . Additionally, in the event of any adverse reaction due to the medication, treatment can be stopped immediately, simply by removing the formulation/patch at any time. In addition, the transdermal route also allows prolonged release of the drug and, therefore, a prolonged therapeutic effect (2, 3). Generally, the success of topical or transdermal drug delivery relies on the ability of the drug to cross the barrier of the stratum corneum of the skin. Although the stratum corneum barrier can be overcome to some extent through the use of penetration enhancers, this approach is not likely to significantly improve drug bioavailability in muscle or tissue anymore. deep due to the rapid skin clearance of the drug (4). Drug absorption in deep tissues such as muscles and joints can be improved by reducing skin clearance using vasoconstrictors. Several research groups have shown that the use of vasocons...

Navigation