Breeding focused on meat production has improved over time thanks to the strict genetic selection that is implemented to conserve and transmit from generation to generation characteristics such as marbling and tenderness of beef. Variations in beef tenderness between breeds have been reported by Marshall (1999) and Burrow et al. (2001); It is one of the most valued attributes (Miller, 1992; Boleman et al., 1997). Many genetic traits linked to meat quality involve a specific number of genes, with some genes in particular expressing a significant proportion of the variability in meat composition and quality (Burrow et al., 2001). The objective is to identify candidate genes in meat expression. quality of beef, one of the candidate genes is the PPARGC1 gene which codes for the peroxisome proliferator-activated receptor gamma coactivator 1 alpha, which is a cofactor which is involved in the transcription of certain genes, including MEF2 (Muscle Enhancer Factor) which concerns adipose tissue. The cells are linked to marbling, because it co-activates PPAR€, PPAR and thyroid hormones (Puigserver, et al., 1998) allowing the fixation of intramuscular fat. Another gene of great importance in meat improvement is the capn1 gene (large subunit of μ-calpain) which has been associated with sensitivity (Smith et al., 2000; Page et al., 2002 , 2004); In the case of the ppargc1a gene, a high frequency of heterozygotes (CT) was observed. The C allele has been considered the most favorable for meat tenderness (White et al., 2005). Currently, SNPs (single nucleotide polymorphisms) have been reported in Leptin proteins,...... middle of article. ..nes of G and A in the two populations of Colombian Creole cattle (B. Taurus and B. Indicus) which are directly linked to the production of lean meat and the content of good marble. acteon.webs.upv.es/CONGRESOS/AIDA%202003/checa.pdfhttp://biblioteca.ucm.es/tesis/vet/ucm-t26294.pdfhttp://www.redalyc.org/pdf/495/49520788041. pdfhttp:// rccp.udea.edu.co/index.php/ojs/article/view/777/840http://www.uco.es/conbiand/aica/templatemo_110_lin_photo/articulos/2012/Trabajo072_AICA2012.pdfhttp:// biblioteca.ucm.es/tesis/vet/ucm-t26294.pdfhttp://itzamna.bnct.ipn.mx/dspace/bitstream/123456789/8886/1/ANAGENES.pdfhttp://www.colvema.org/pdf/ 6473geneticii.pdf